NIH seeks volunteers for at-home COVID-19 antibody test as study looks to find undetected cases

U.S. & World

A rendering of coronavirus via the CDC.

LOS ANGELES (KTLA) – Federal health officials are recruiting up to 10,000 volunteers nationwide as they investigate just how pervasive the novel coronavirus has been in the United States.

As of Monday, more than 550,000 people in the U.S. have tested positive for COVID-19 in the U.S. But with milder and asymptomatic cases often going undiagnosed, researchers are turning to antibody tests to figure out the extent of the virus’ spread, according to a news release from the National Institutes of Health.

Researchers are also hoping to gain insight into which populations and communities have been most impacted, officials said.

Using blood samples from up to 10,000 volunteers nationwide, the “serosurvey” will determine how many adults without a confirmed diagnoses have been been infected, the release stated.

“This study will give us a clearer picture of the true magnitude of the COVID-19 pandemic in the United States by telling us how many people in different communities have been infected without knowing it, because they had a very mild, undocumented illness or did not access testing while they were sick,” said Dr. Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases, in the release.

The study is being conducted by researchers from the NIAID, as well as other centers within the NIH.

Participants will have blood samples tested for the presence of two types of antibodies, anti-SARS-CoV-2 S protein IgG and IgM, to determine if they were previously infected by and recovered from with the highly contagious respiratory illness.

“These crucial data will help us measure the impact of our public health efforts now and guide our COVID-19 response moving forward,” said Fauci, who is also a member of the president’s coronavirus task force.

The vast majority of testing in the U.S. conducted thus far has been used to identify active infections and can’t determine whether a person previously contracted COVID-19.

“An antibody test is looking back into the immune system’s history with a rearview mirror,” said Dr. Matthew J. Memoli, principal investigator of the study and director of NIAID’s Laboratory of Infectious Diseases Clinical Studies Unit, in the release. “By analyzing an individual’s blood, we can determine if that person has encountered SARS-CoV-2 previously.”

The federal agency isn’t the only one performing such an analysis. In California, scientists from Stanford Medicine launched antibody testing last week on a regional level, as did USC’s Price School of Public Policy in conjunction with Los Angeles County Department of Public Health.

For the NIH study, volunteers can participate from anywhere in the U.S., provided the individual is healthy and over the age of 18. Anyone who has previously tested positive for COVID-19 or shown symptoms of the virus currently is ineligible.

Those selected to participate in the study can have their blood drawn at the NIH campus in Bethesda, Maryland, or they can do it at home through an in-home blood collection provided by the Torrance-based medical device firm Neoteryx.

Those interested in joining the study are asked to contact the agency via email at

More information can also be found in a questions-and-answers guide here.

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April 29 2021 12:00 am

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