The California Highway Patrol is investigating after a man was killed in a head-on collision near Chowchilla.
It happened just after 2 a.m. Wednesday morning, on Highway 152.
CHP said the driver of a white sedan was going the wrong way and collided head-on with a big rig.
It is still unknown if alcohol or drugs played a factor in the crash.
The truck driver was not harmed and the identity of the driver is not yet being released.
CHP expects the road to be reopened at 6 a.m.